How does NUCALA work?

NUCALA gets to it—targeting and reducing eosinophils, a key source of asthma inflammation.

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NUCALA logo; Nucala (mepolizumab) Injection 100 mg/mL

How NUCALA (mepolizumab) works.
The mechanism of action of NUCALA is not fully understood.

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Asthma is a chronic lung disease that inflames and narrows the airways. Asthma causes symptoms such as wheezing, chest tightness, shortness of breath, and coughing. So, how are the airways involved? Let’s take a closer look.

NARRATOR:
In a person without asthma, we can see how air is able to move easily through the airway. But in a person with asthma, inflammation and constriction can affect how air flows through the airways.

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Inflammation can make an airway irritated and swollen with increased mucus. This narrows the airways, which can decrease airflow. A variety of cells including eosinophils, are involved in inflammation.

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Eosinophils are a type of white blood cell that are a normal and necessary part of your immune system.

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EOSINOPHILS

NARRATOR:
Eosinophils play an important part in the body’s response to allergic reactions, asthma, and infections. They help to protect against certain infections but can contribute to inflammation.

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EOSINOPHILS
RED BLOOD CELLS

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Eosinophils are in the blood and tissue.

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In a small population of people with asthma, when there are too many eosinophils, they can worsen inflammation in the lungs. This inflammation can cause ongoing symptoms and asthma attacks–also known as exacerbations or flare-ups. This is known as eosinophilic asthma.

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While the mechanism of action of NUCALA is not fully understood, NUCALA targets eosinophils in the body.

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The mechanism of action of NUCALA is not fully understood.

NARRATOR:
NUCALA binds to a protein called interleukin or IL-5, which plays a key role in eosinophil production.

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IL-5
NUCALA

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NUCALA blocks IL-5 from making more eosinophils. Having less eosinophils can help reduce inflammation. This may lead to fewer asthma attacks.

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NUCALA logo; Nucala (mepolizumab) Injection 100 mg/mL
Please see full Prescribing information, including Patient Information, for NUCALA available at www.NUCALA.com.
For US audiences only.
Trademarks are owned by or licensed to the GSK group of companies.
[GSK logo]
©2023 GSK or licensor.
MPLVID200037 July 2018
Produced in USA.

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The mechanism of action of NUCALA is not fully understood.

 

Here’s the facts:

NUCALA targets eosinophils

NUCALA targets eosinophils

Eosinophils [ee-uh-sin-uh-fils] are white blood cells that are a normal part of the body’s immune system.

  • What this means for your severe asthma: Too many eosinophils may lead to inflammation in your lungs. Inflammation can cause severe asthma attacks.
NUCALA reduces eosinophils

NUCALA reduces eosinophils

NUCALA is not a steroid like prednisone. It is designed to reduce the number of eosinophils in your blood.* Reducing the number of eosinophils in your blood may help reduce airway inflammation.

  • What this means for your severe asthma: NUCALA helps you improve asthma control and helps reduce your use of oral steroids like prednisone.† It’s important to receive your injection of NUCALA once every four weeks as prescribed, even if you’re feeling better.

    *The mechanism of action of NUCALA is not fully understood.

    †Results may vary.

Blood test

Simple blood testing can measure the number of eosinophils in your blood

In clinical studies, this helped identify patients whose asthma was more likely to respond to treatment with NUCALA.

  • What this means for your severe asthma: Based on your test results, along with your medical history and other information, your doctor may add NUCALA to your treatment.

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Why NUCALA?

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Learn about NUCALA